Indlela Amadoda nabafazi abenza ngayo uloyiko lweNkumbulo

Ngabasebenzi beBongo kunye nokuziphatha

Amadoda nabasetyhini banokuchaphazeleka okwahlukileyo kubuchwephesha- kunye noxinzelelo olunxulumene noxinzelelo njengoxinzelelo kunye noxinzelelo lwasemva koxinzelelo (PTSD), izifundo ezidlulileyo zityhile. Umzekelo, abasetyhini bakhulisa i-PTSD kabini kwinqanaba lamadoda. Abaphandi bafuna ukwazi ukuba kutheni le nto kunjalo.

Umzimba okhulayo wobungqina ubonakalisa ukuba iinkqubo zamadoda nabasetyhini zoyika iinkumbulo ngokwahlukileyo. Uphando olutsha kwiimpuku ezivela kwiqela elikhokelwa ngu-2016 BBRF Umphandi oselula u-Elizabeth A. Heller, Ph.D., weYunivesithi yasePennsylvania, umisela ezinye zeendlela ezichaphazelekayo. Ukuqonda ezi ndlela kunokunceda kuphuhliso lwexesha elizayo lonyango oluthile ngokwesini lokuphazamiseka koxinzelelo.

Iziphumo zokugqibela zeqela zichazwe kwi-Intanethi kwi-Biological Psychiatry ngo-Disemba 5, 2018. Bacebisa ukuba ukumiselwa kofuzo ekuthiwa yi-Cdk5 ngumthombo obalulekileyo umahluko kwindlela amadoda nabasetyhini abenza ngayo uloyiko kwinkumbulo. Umahluko wabonwa kwingqondo yehippocampus, iziko lokwakheka kwememori, ukufunda, kunye nokuqhelaniswa nendawo.

Indaleko ivelise iindlela ezahlukeneyo ezithi iiseli zilawule indlela esebenza ngayo imizila yemfuza yazo — indlela ezijika ngayo zize zicime ngamaxesha athile. Inkqubo yokulawula efanelekileyo kwiCdk5 kunye nokulungiswa kweenkumbulo zoyika kuthiwa ngummiselo we-epigenetic. Olu hlobo lommiselo wemfuza sisiphumo sokulungiswa kweemolekyuli, ezibizwa ngokuba ngamanqaku epigenetic, ukongezwa okanye ukususwa kulandelelwano lwe-DNA "olupela" ufuzo. Ngokudibanisa okanye ngokuthabatha amanqaku epigenetic, iiseli ziyakwazi ukwenza okanye ukucima ii-genes ezithile.

Sebenzisa iimpuku njengommeli wabantu-ubuchopho begundane bufana kakhulu kwiinkalo ezininzi, kubandakanya neenkqubo zolawulo lwemfuza-uGqr. U-Heller kunye noogxa bakhe bafumanise ukuba ukubuyisa iinkumbulo zoyika ixesha elide kunamandla emadodeni kunabafazi. Isizathu: ukwanda kokusebenza kweCdk5 emadodeni, okubangelwa ngamanqaku epigenetic. Ukusebenza kwenzeka kwiiseli zemithambo-luvo kwihippocampus.

Sebenzisa ubuchule benoveli obubizwa ngokuba yi-epigenetic editing, uGqr Heller kunye noogxa bakhe babenako ukufumanisa indima ethe ngqo yabasetyhini ekusebenzeni kweCdk5 ekwenzeni buthathaka ukubuyiswa kweenkumbulo zoloyiko. Oku kube neziphumo ezichaphazela ababhinqileyo kwityathanga lezinto ezenzeka emva kokusebenza kohlobo.

Ezi zinto zifunyanisiweyo ziyinxalenye yokuqonda kwethu okukhulayo kokwahluka kwezesondo kwibhayoloji yokuba iziganeko ezoyikekayo zikhunjulwa njani kwaye zibonisa ukuba kutheni isondo kuyinto ebalulekileyo kwingqondo nakwindlela yokuziphatha ebandakanya uloyiko noxinzelelo, njenge-PTSD, uxinzelelo kunye noxinzelelo.