Isifo sokuSebenza kweseli esinzulu: Isilumkiso koGqirha bengqondo

Izigulana ezininzi ezibiza ukuba zicela ukubonisana noogqirha bokuqala abanengxaki yemeko eqhelekileyo eyaziwa njenge-mast cell activation syndrome (i-MCAS). I-MCAS inokubonisa ngeempawu eziguquguqukayo eziguquguqukayo. Inkungu yobuchopho, unxunguphalo, uxinzelelo kunye nokungalali ziphakathi kweempawu eziqhelekileyo. Ngelishwa lilishwa lokuba i-MCAS ayikho kwi-radar yoogqirha bezigulo zengqondo.

Xa isigulana sinika ingxelo yokuqunjelwa okukhulu okuhamba kunye ne-15 yeepawundi yokufumana ubunzima ngeveki, okanye banokuthi batye kuphela ukutya okuthintelweyo ngenxa yokuba banokuphendula okungathandekiyo kwangoko ekutyeni, okanye bafumana iimpawu ezothusayo zemithambo-luvo, okanye -novakalelo kuhlobo olwahlukeneyo lwezinto ezikhuthazayo, ngokukhawuleza ndiyazibuza ukuba ngaba iMCAS iyadlala. Kwezinye izigulana, ukwamkelwa kunye nokunyangwa kwale meko kuye kwenza umahluko omkhulu ngokubhekisele kuncedo olukhawulezileyo lweempawu.

UNeil Nathan, MD ubhale isahluko esihle kakhulu kwincwadi yakhe entsha enesihloko esithi Inetyhefu malunga neMCAS. (iphepha 99-114).

Iimpawu uGqirha uNathan uluhlu olunokubakho kwi-MCAS kubandakanya:

• Uxinzelelo olunzulu kunye noxinzelelo
• Intlungu ebukhali enokuthi yenzeke kumalungu, izihlunu, imisipha kunye / okanye amathambo
• Iimpawu ezingaqhelekanga ze-neurological ezinje ngokuba ndindisholo kunye nokutswina kwiindawo ezahlukeneyo zomzimba, ukukhubazeka, kunye ne-pseudoseizures
• Intloko ebuhlungu
• Iyakhala ezindlebeni
• Ubuntununtunu kuluhlu olubanzi lwezinto ezikhuthazayo, njengokukhanya, ukuchukumisa, isandi, amavumba, ukutya, iikhemikhali kunye nokuhamba rhoqo kwe-electromagnetic (EMF)
• Umqala obuhkungu
• Ukudumba kwamadlala
• Ukugaya, kubandakanya urhudo, ukuqhina, ukuqunjelwa, igesi kunye nesilungulela
• Ukudinwa okungapheliyo
• Ukuphuthelwa
• Ubunzima bokuqonda, kubandakanya inkungu yengqondo kunye nokwehla kokugxila, inkumbulo kunye noxinzelelo
• Intlungu yePelvic
• I-cystitis yangaphakathi (ukudumba okubuhlungu kwesinyi)
• Ukuqhawukelwa ngumphefumlo
• Indlala yomoya (imvakalelo yokungakwazi ukuthatha umphefumlo onzulu)
• Irhashalala
• Ubunzima ngokulingana kunye nokulinganisela

Xa abaguli bethetha nogqirha wabo ophambili ngezikhalazo ezininzi ezibonakala zingacacanga ezichaphazela iimpawu ezingahambelaniyo zomzimba, ezihlala zibonisa iimpawu zengqondo, badla ngokucinga ukuba banesifo sengqondo kwaye baxelele "konke oku kusentloko yakho." Banokuthunyelwa ekhaya kunye nonyango lweyeza lokuthomalalisa uxinzelelo okanye amayeza okulwa noxinzelelo, elinganeli nje kuphela ukuba linokungasebenzi kodwa alisijongisi oyena nobangela weempawu zabo.

Ukuchonga i-MCAS njengomthombo weempawu kunokubaluleka kunyango kwaye kunokukhawulezisa ukubuyisela kwimeko yesiqhelo.

Iiseli ezincinci ziiseli ezimhlophe zegazi eziyinxalenye yesistim somzimba kwaye zisebenza njengebhulorho phakathi kwamajoni omzimba kunye nenkqubo yovalo, esebenza ukulungelelanisa ezi zimbini. Umsebenzi wabo ophambili kukukhusela iityhefu kunye nezinto ezichaphazelayo.

Iiseli ezincinci zinokufumaneka kuwo onke amalungu omzimba, kodwa ezona ndawo kugxilwe kuzo zikwindawo zomzimba ezinxibelelana nehlabathi langaphandle kwaye ngenxa yoko zichaphazeleka kusulelo nakwiityhefu. Oku kubandakanya iisono, umqala, isisu, indlela yokuphefumla, ulusu, kunye nendawo yolusu.

Iiseli ezincinci zigcwaliswa ngee-vesicles ezibizwa ngokuba ziigranules eziqulathe ngaphezulu kwe-200 eyahlukeneyo yeempawu zebhayoloji. Xa kufakwa i-toxin okanye i-arhente echaphazelayo, umntu onesistim somzimba esisebenza kakuhle uya kudibanisa iiseli zakhe zemilenze ukuze alungelelanise impendulo efanelekileyo. Iiseli zemasti zikhupha abalamli bazo begazi, ngakumbi i-histamine, i-serotonin kunye ne-tryptase, ukuthomalalisa ubungozi.

Ukuba amajoni omzimba omntu atyhafile kwaye anehyperous, iiseli zemasti zinokusebenza kakhulu. Endaweni yokukhulula abalamli babo kwi-biochemical ngendlela efanelekileyo yokuzikhawulela, baye bangalungelelaniswa kwaye bathotye isidima, kubangele uluhlu lweempawu ezidweliswe apha ngasentla.

Unyango lubandakanya ukuzinzisa inwebu yeeseli zemasti ukuze zingathobi isidima kunye nokuzola kwenkqubo yemithambo-luvo.

Kwezinye izigulana, ii-antihistamines eziqhelekileyo ezingaphaya kwamanani kunokuba luncedo. Ukuphuculwa kunokuba kwangoko okanye kungathatha ukuya kwiinyanga ezimbini. Olunye uzinzo lwe-mast cell yi-quercetin, ilungu losapho lwe-vitamin C. Olunye unyango olunokuba luncedo yi-histamine-2 blocker, famotidine.

Kukho izinto zendalo ezinokuba luncedo kunye namayeza kagqirha.

Abanye abaguli abane-MCAS baxhamla kwisondlo esisezantsi se-histamine. Kubalulekile ukufumanisa ukuba ngaba ukutya okunje kuyawenza umahluko kuba akunampilo ukuthintela ukutya ngokungafunekiyo.

Ngokwendlela yokujongana ne-hyperarousal yenkqubo yemithambo-luvo, ndihlala ndincoma inkqubo yeDynamic Neural Retraining System (DNRS), inkqubo enamava edibanisa izinto ezinokuthanani nonyango lokuziphatha, ukuhlengahlengisa kwengqondo okusekwe engqondweni, unyango lokwenza uhlengahlengiso ngokweemvakalelo, inkqubo yolwimi ye-neural, uqeqesho olongezelelekileyo (uhlobo lwe-neural shaping) kunye nokulungiswa kokuziphatha kunyango lwe-rewire neural circuits kwinkqubo ye-limbic system, ethomalalisa impendulo yoxinzelelo.

Nangona ukunyanga i-MCAS kuluncedo ekunikezeleni ukukhululeka kweempawu, kukho isidingo sokujongana nesizathu esiyintloko ukuze isigulana siphilise.

Isibonelelo esipheleleyo malunga ne-MCAS yincwadi ka-2016 kaLawrence Afrin MD, Ungaze ubheje ngokuchasene ne-Occam: Isifo esiSebenzayo seSeli esiSifo kunye noBhubhane wale mihla weSifo esinganyangekiyo kunye nobunzima bezoNyango.

I-Afrin, uLawrence (2015) Ungaze ubheje ngokuchasene ne-Occam: Isifo esiSebenzayo seSeli esiNgesifo kunye noGawulayo wale mihla weSifo esinganyangekiyo kunye nabaSisi abaXakekileyo kwiZonyango Media LLC

U-Lysander Jim, u-Yvonne Berry, u-Ming Dooley, u-James Ryan, u-Scott McMahon (i-2018) Inkqubo yoNyango ye-Inflammatory Response Syndrome (i-CIRS): Ingxelo ye-Consensus Statement yoPhononongo lwaMayeza lwaNgaphakathi iVolume yesi-4