Into ekufuneka uyazi ngokulala kunye ne-Alzheimer's

Ndisebenza yonke imihla ukugcina ingqondo yam ikwimo entle. Ndifundile, ndidlala imidlalo nabantwana bam (Amagama nabahlobo, nabani na?), Thatha izongezo, uyithiye igama. Nditya ukutya okugxininisa ukutya kwengqondo-kubandakanya ezo omega 3s ndibhale ngazo kutshanje. Ndiyaqinisekisa ukuba ndilala ngokwaneleyo.

Ndisebenza nzima namhlanje ukuze ubuchule bam bokuqonda buhlale bomelele amashumi eminyaka phantsi kwendlela.

Kodwa ukuphila ngendlela esempilweni akusigcini sinexhala malunga nemingcipheko yexesha elide yokwehla kwengqondo kunye nezifo ze-neurodeergenerative ezinjenge-dementia. Uninzi lwezigulana zam ezihamba phakathi kweminyaka yokuthetha nam malunga noloyiko lwabo lokuphulukana nenkumbulo, ukucaca kwengqondo, kunye nemisebenzi yokuqonda kunye nobudala-kunye neenkxalabo zabo malunga ne-Alzheimer's ngokukodwa.

Kukho uphando olutsha malunga nokunxibelelana phakathi kokulala kunye ne-Alzheimer ndifuna ukwabelana nawe-uphando olwenza nzulu ukuqonda kwethu ukuba ukulala kakubi kunye nesifo se-Alzheimer kunxibelelene njani. Uninzi lwethu mhlawumbi luyazi, okanye luyazi, umntu ochaphazelekayo yi-Alzheimer's. Ngelishwa, amanani ayayiveza loo nto. Ngokwe-Alzheimer's Association, umntu othile e-US uvelisa isifo se-Alzheimer rhoqo kwimizuzwana engama-65. Namhlanje, kukho i-5.7 yezigidi zabantu baseMelika abaphila nesi sifo se-neurodeergenerative-olona hlobo luqhelekileyo lwesifo sengqondo esixhalabisayo. Ngo-2050, uqikelelo lubonisa ukuba elo nani liza kunyuka liye kwizigidi ezili-14.

Yintoni ebangela isifo se-Alzheimer?

Impendulo enzima kukuba, okwangoku asazi. Izazinzulu zisebenza nzima zichonga izizathu ezingunobangela we-Alzheimer. Nangona singekasazi ukuba kutheni, kodwa esikwaziyo kukuba isifo sibangela iingxaki ezisisiseko kwindlela iiseli zengqondo ezisebenza ngayo.

Iibhiliyoni ze-neurons kwingqondo yethu zihlala zisebenza, zisigcina siphila kwaye sisebenza. Basenza ukuba sikwazi ukucinga nokwenza izigqibo, sigcine kwaye sifumane inkumbulo kunye nokufunda, amava kwihlabathi elisingqongileyo ngokusebenzisa izivamvo zethu, sive uluhlu lwethu lweemvakalelo, kwaye sizivakalise ngolwimi kunye nokuziphatha.

Izazinzulu zicinga ukuba kukho iintlobo ezininzi zeeproteyini ezibangela ukuthotywa kweeseli zengqondo, zikhokelela kwiingxaki eziqhubeka ngokuthe kratya kwimemori, ukufunda, imo yokuziphatha kunye nokuziphatha- iimpawu ezibonakalayo ze-Alzheimer's. Ezimbini kwezo proteni zezi:

• Iiproteni zeBeta-amyloid, ezakhayo zenze iiplagi ezijikeleze iiseli zengqondo.
• Iiproteni ze-Tau, ezikhula zibe ngamaqhina afana ne-fiber-aziwa njenge-tangles-ngaphakathi kweeseli zengqondo.

Izazinzulu zisasebenza ukuqonda ukuba iipleyiti kunye neetangles zinegalelo njani kwisifo se-Alzheimer kunye neempawu zayo. Ngobudala, kuqhelekile ukuba abantu baphuhlise ezinye zezi zakhi kwingqondo. Kodwa abantu abane-Alzheimer bakhulisa iiplagi kunye neetangali ngexabiso elikhulu kakhulu-ngakumbi kwiindawo zobuchopho ezinxulumene nememori kunye neminye imisebenzi yokuqonda.

Kukho umzimba okhulayo wophando obonisa ukulala okungalunganga kwaye ukungalali ngokwaneleyo kunxulunyaniswa nezixa ezikhulu zeeproteni ze-beta-amyloid kunye ne-tau kwingqondo. Olunye uphononongo olwakhutshwa ngo-2017 lwafumanisa ukuba kubantu abadala abasempilweni, abaphakathi, ukuphazanyiswa kokulala kancinci kwamaza kunxulunyaniswa namanqanaba okwanda kweeproteni ze-beta-amyloid.

Ukulala emini kunxulunyaniswa ne-Alzheimer's enxulumene neeprotein kwingqondo

Uphononongo olusandula ukukhutshwa lubonisa ukuba ukulala kakhulu emini kunxulunyaniswa nexabiso eliphezulu leeprotein ze-beta-amyloid zobuchopho kubantu abadala abasempilweni. Oososayensi kwikliniki yaseMayo babeke kwisifundo sabo ukuphendula umbuzo omkhulu malunga nobuzaza: ngaba ukwakhiwa kweprotein ye-beta-amyloid kunegalelo ekungalali kakuhle, okanye ukuphazamiseka kokulala kukhokelela ekuqokeleleni kwezi proteni?

Ikliniki yaseMayo sele inesifundo sexesha elide malunga notshintsho lwengqondo olunxulumene nokwaluphala. Ukusuka kolo phando sele luqhutywa, izazinzulu zikhethe abantu abangama-283, ababeneminyaka engaphezulu kwama-70 kwaye bengenaso isifo sengqondo esixhalabisayo, ukuphanda ubudlelwane phakathi kweendlela zabo zokulala kunye nomsebenzi wabo we-beta-amyloid protein.

Ekuqaleni kophononongo, phantse ikota enye-ngaphezulu kancinci kweepesenti ze-22 zabantu abadala abakweli qela baxele ukuba babelala kakhulu emini.Ukulala kakhulu emini, ngokuqinisekileyo, sisalathiso sokuqala awufumani ukulala ngokwaneleyo ebusuku-kwaye luphawu olunxulunyaniswa nokuphazamiseka kokulala, kubandakanya ukulala.

Kwisithuba seminyaka esixhenxe, izazinzulu zijonge umsebenzi wezigulana ze-beta-amyloid zisebenzisa i-PET scan. Bafumene:

Abantu abalala kakhulu emini ekuqaleni kophononongo kunokwenzeka ukuba babe namanqanaba aphezulu e-beta-amyloid ekuhambeni kwexesha.

Kwaba bantu balale ukulala, inani elibalulekileyo lokwakha i-beta-amyloid lenzeke kwiindawo ezimbini zobuchopho: i-anterior cingate kunye ne-cingulate precuneus. Kubantu abane-Alzheimer's, ezi ndawo zimbini zobuchopho zihlala zibonisa amanqanaba aphezulu okwakhiwa kwe-beta-amyloid.

Olu phononongo aluniki mpendulo ichanekileyo kumbuzo wokuba ingaba bubuthongo obungalunganga na obuqhuba i-amyloid protein eyakhayo, okanye iidipozithi ze-amyloid ezibangela iingxaki zokulala- okanye ezinye zazo zombini. Kodwa iyacebisa ukuba ukulala kakhulu emini kunokuba luphawu lwesilumkiso kwangoko sesifo se-Alzheimer's.

Uphononongo lweMayo Clinic luhambelana nophando lwamva nje olwajonga ubudlelwane phakathi kokulala kakubi kunye nomngcipheko we-Alzheimer. Izazinzulu kwiDyunivesithi yaseWisconsin, uMadison waphanda unxibelelwano olunokubakho phakathi komgangatho wokulala kunye neempawu ezibalulekileyo zeAlzheimer's, ezifumaneka kulwelo lomqolo, kubandakanya amanqaku eeproteni ze-beta-amyloid kunye neeproteni ze-tau ezikhokelela kwimingxunya yesele ye-nerve.

Kolu phando, oosonzululwazi bavavanya abantu ngaphandle kwe-Alzheimer's okanye isifo sengqondo esixhalabisayo-kodwa bakhetha ngokukodwa abantu ababesemngciphekweni omkhulu wesifo, mhlawumbi ngenxa yokuba babenomzali onesifo i-Alzheimer okanye ngenxa yokuba babephethe uhlobo oluthile (i-apolipoprotein E gene), inxulunyaniswa nesi sifo.

Njengabalingani babo eMayo, abaphandi baseMadison bafumanisa ukuba abantu abafumana ubuthongo obugqithisileyo emini babonisa amanqaku angaphezulu kwiprotein ye-beta-amyloid. Bafumene ukulala emini kunxulunyaniswa namanye amanqaku eeproteni ze-tau. Kwaye abantu abaxele ukulala kakubi kwaye babenengxaki enkulu yokulala babonisa ngakumbi ii-biomarker ze-Alzheimer kunabalingani babo bokulala.

Ingqondo iyazihlambulula iiproteni ezinxulumene ne-Alzheimer xa ulele

Kwakwiminyaka nje embalwa edlulileyo apho oososayensi bafumanisa khona inkqubo eyayingaziwa ngaphambili kwingqondo ecoca inkunkuma, kubandakanya neeproteni ze-beta-amyloid ezinxulumene ne-Alzheimer's. (IYunivesithi yaseRochester Medical Centre izazinzulu eziye zafumanisa le nto ziyibiza ngokuba yi "glymphatic system," kuba isebenza kakhulu njenge-lymphatic system yomzimba ekususeni inkunkuma emzimbeni, kwaye iqhutywa ziiseli zobuchopho.) t chonga nje inkqubo ye-Olympicic-ukufumanisa okuqhekezayo kunye nako. Bafumanise ukuba inkqubo ye-Olympics iya kwi-overdrive ngexesha lokulala.

Xa silele, izazinzulu ziye zafumanisa ukuba, inkqubo ye-Olympicic iba ngamaxesha angama-10 asebenza ngakumbi ekucoceni inkunkuma ebuchotsheni.

Olu lolunye lolona phando lunyanzelisayo okwangoku ukubonisa ukubaluleka kokulala okunempilo kwimpilo yeengqondo yexesha elide. Xa ulele, izazinzulu ngoku ziyacinga, inkqubo yakho ye-Olympic inyusa umsebenzi wayo wokususa inkunkuma enobungozi ethe yaqokelelwa ngosuku lwakho lokuvuka. Ukuba ulala kakubi okanye ungalali ngokwaneleyo, ubeka emngciphekweni wokuphoswa ziziphumo zokucoca.

Imijikelo yokulala ngokungaqhelekanga enxulunyaniswa ne-Alzheimer's

Olunye uphawu lokulumkisa ulwalamano lwe-Alzheimer's? Ukuphazamiseka kwiipateni zokulala, ngokophando olutsha. Oososayensi kwiYunivesithi yaseWashington University of Medicine balandelela isingqisho sokujikeleza kunye nemijikelezo yokulala yabantu abaphantse babe ngama-200 abadala (iminyaka yobudala, i-66), kwaye babavavanya bonke kwangoko, imiqondiso yangaphambi konyango lwe-Alzheimer's.

Kwizigulana ezingama-50 ezibonakalise iimpawu zangaphambi konyango lwe-Alzheimer's, bonke baphazamise imijikelezo yokulala. Oko kwakuthetha ukuba imizimba yabo yayingabambeleli kwimodeli ethembekileyo yokulala ebusuku kunye nomsebenzi wasemini. Baye bakwazi ukulala kancinci ebusuku, kwaye bathambekele ekulaleni ngakumbi emini.

Inye kuphela into ebalulekileyo ekufuneka uyiqaphele apha: Abantu abakwisifundo abaphazamise imijikelezo yokuvuka kokulala babengengabo bonke ubuthongo bokulala. Babelala ngokwaneleyo — kodwa babeqokelela ubuthongo kwisahlulo esahlukileyo ngaphezulu kosuku lweeyure ezingama-24.

Olu phononongo lubonisa ukuba ukuphazamiseka kwesingqi esijikelezayo kunokuba yinto yokuqala kakhulu kwi-Alzheimer's, nokuba akukho kulala.

Xa abaguli bam besabelana nam ngexhala labo malunga nempilo yabo yexesha elide kunye noloyiko lwabo lwe-Alzheimer's, ndiyayiqonda. Ndiza kukuxelela into endibaxelela yona: eyona nto unokuyenza kukuguqula uxinzelelo lwakho lube luthintelo kwaye uzikhathalele namhlanje, ngenjongo yokwehlisa umngcipheko wokuhla kwengqondo kunye nesifo sengqondo esixhalabisayo. Ukujonga konke esikwaziyo, kuyacaca ukuba ukulala ubuninzi, umgangatho ophezulu wokulala yinxalenye ebalulekileyo yesicwangciso somsebenzi.

Amaphupha amnandi,
UMichael J. Breus, PhD, DABSM
Ugqirha wokulala ™
www.kwefitsa.com